BDBM767014 2-(6-(6-((6-(4-fluoro-1H-pyrazol-1-yl) pyridin-3-yl) methyl)-3,6-diazabicyclo [3.1.1] heptan-3-yl) pyridin-3-yl)-6-methyl-N-(5-methyl-1H-pyrazol-3-yl) pyrimidin-4-amine ::US20250268897, Compound 1-A

SMILES Cc1cc(Nc2cc(C)[nH]n2)nc(-c2ccc(N3CC4CC(C3)N4Cc3ccc(-n4cc(F)cn4)nc3)nc2)n1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 767014   

TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810S](Human)
Sichuan Kelun-Biotech Biopharmaceutical Co.

US Patent
LigandPNGBDBM767014(2-(6-(6-((6-(4-fluoro-1H-pyrazol-1-yl) pyridin-3-y...)
Affinity DataIC50: 2.69nMAssay Description:The three drug-resistant mutant RET enzymes were each pre-incubated with different concentrations of test compounds (in the inhibition rate test of t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/8/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Human)
Sichuan Kelun-Biotech Biopharmaceutical Co.

US Patent
LigandPNGBDBM767014(2-(6-(6-((6-(4-fluoro-1H-pyrazol-1-yl) pyridin-3-y...)
Affinity DataIC50: 19.6nMAssay Description:The three drug-resistant mutant RET enzymes were each pre-incubated with different concentrations of test compounds (in the inhibition rate test of t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/8/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810C](Human)
Sichuan Kelun-Biotech Biopharmaceutical Co.

US Patent
LigandPNGBDBM767014(2-(6-(6-((6-(4-fluoro-1H-pyrazol-1-yl) pyridin-3-y...)
Affinity DataIC50: 53.2nMAssay Description:The three drug-resistant mutant RET enzymes were each pre-incubated with different concentrations of test compounds (in the inhibition rate test of t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/8/2025
Entry Details
US Patent