BDBM767727 (1r,3r)-3-(cyanomethyl)-3-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl)-3-(methyl amino)-1H-pyrazol-1-yl)cyclobutane-1-carbonitrile::US12404275, Example 38

SMILES CNc1nn([C@]2(CC#N)C[C@@H](C#N)C2)cc1-c1nc(-c2cnn(C)c2)cn2nccc12

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 767727   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Primegene (Beijing) Co.

US Patent
LigandPNGBDBM767727((1r,3r)-3-(cyanomethyl)-3-(4-(6-(1-methyl-1H-pyraz...)
Affinity DataIC50: 0.330nMAssay Description:A compound (powder) was dissolved in 100% DMSO to prepare a 10 mM storage solution. The compound had an initial test concentration of 10,000 nM or 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/11/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Primegene (Beijing) Co.

US Patent
LigandPNGBDBM767727((1r,3r)-3-(cyanomethyl)-3-(4-(6-(1-methyl-1H-pyraz...)
Affinity DataIC50: 6.70nMAssay Description:A compound (powder) was dissolved in 100% DMSO to prepare a 10 mM storage solution. The compound had an initial test concentration of 10,000 nM or 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/11/2025
Entry Details
US Patent