BDBM768400 (E)-1-(6-(4-((4- ([1,2,4]triazolo[1,5- a]pyridin-7-yloxy)-3- methylphenyl)amino) pyrrolo[2,1-f][1,2,4]triazin- 5-yl)-2- azaspiro[3.3]heptan-2- yl)-4- (dimethylamino)but-2- en-1-one::US20250276983, Example 95::US20250345339, Compound 13

SMILES Cc1cc(Nc2ncnn3ccc(C4CC5(C4)CN(C(=O)/C=C/CN(C)C)C5)c23)ccc1Oc1ccn2ncnc2c1

InChI Key

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 768400   

LigandChemical structure of BindingDB Monomer ID 768400BDBM768400((E)-1-(6-(4-((4- ([1,2,4]triazolo[1,5- a]pyridin-7...)
Affinity DataIC50: 200nMAssay Description:The purpose of the wtERBB2, ERBB2-A775_G776insYVMA (ERBB2YVMA), wtEGFR biochemical assay was to evaluate the inhibition (% inhibition and IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details

LigandChemical structure of BindingDB Monomer ID 768400BDBM768400((E)-1-(6-(4-((4- ([1,2,4]triazolo[1,5- a]pyridin-7...)
Affinity DataIC50: 200nMAssay Description:The radioactive signal generated from the aliquot of buffer solution was proportional to the amount of radiolabeled substrate produced, and which is ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/15/2025
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 768400BDBM768400((E)-1-(6-(4-((4- ([1,2,4]triazolo[1,5- a]pyridin-7...)
Affinity DataIC50: 200nMAssay Description:The radioactive signal generated from the aliquot of buffer solution was proportional to the amount of radiolabeled substrate produced, and which is ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/15/2025
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 768400BDBM768400((E)-1-(6-(4-((4- ([1,2,4]triazolo[1,5- a]pyridin-7...)
Affinity DataIC50: 200nMAssay Description:The purpose of the wtERBB2, ERBB2-A775_G776insYVMA (ERBB2YVMA), wtEGFR biochemical assay was to evaluate the inhibition (% inhibition and IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details

TargetEpidermal growth factor receptor(Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 768400BDBM768400((E)-1-(6-(4-((4- ([1,2,4]triazolo[1,5- a]pyridin-7...)
Affinity DataIC50: 350nMAssay Description:The radioactive signal generated from the aliquot of buffer solution was proportional to the amount of radiolabeled substrate produced, and which is ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/15/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 768400BDBM768400((E)-1-(6-(4-((4- ([1,2,4]triazolo[1,5- a]pyridin-7...)
Affinity DataIC50: 350nMAssay Description:The purpose of the wtERBB2, ERBB2-A775_G776insYVMA (ERBB2YVMA), wtEGFR biochemical assay was to evaluate the inhibition (% inhibition and IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details