BDBM768409 (E)-1-(4-(4-((3-methyl-4- ((1-methyl-1H- benzo[d]imidazol-5- yl)oxy)phenyl)amino) pyrrolo[2,1-f][1,2,4]triazin- 5-yl)piperdin-1-yl)-4- (tetrahydro-1H-furo[3,4- c]pyrrol-5(3H)-yl)but-2- en-1-one::US20250276983, Example 105::US20250345339, Compound 15

SMILES Cc1cc(Nc2ncnn3ccc(C4CCN(C(=O)/C=C/CN5CC6COCC6C5)CC4)c23)ccc1Oc1ccc2c(c1)ncn2C

InChI Key

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 768409   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 768409BDBM768409((E)-1-(4-(4-((3-methyl-4- ((1-methyl-1H- benzo[d]i...)
Affinity DataIC50: 200nMAssay Description:The radioactive signal generated from the aliquot of buffer solution was proportional to the amount of radiolabeled substrate produced, and which is ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/15/2025
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2 [1-775,'YVMA',776-1255](Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 768409BDBM768409((E)-1-(4-(4-((3-methyl-4- ((1-methyl-1H- benzo[d]i...)
Affinity DataIC50: 200nMAssay Description:The radioactive signal generated from the aliquot of buffer solution was proportional to the amount of radiolabeled substrate produced, and which is ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/15/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 768409BDBM768409((E)-1-(4-(4-((3-methyl-4- ((1-methyl-1H- benzo[d]i...)
Affinity DataIC50: 200nMAssay Description:The radioactive signal generated from the aliquot of buffer solution was proportional to the amount of radiolabeled substrate produced, and which is ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/15/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 768409BDBM768409((E)-1-(4-(4-((3-methyl-4- ((1-methyl-1H- benzo[d]i...)
Affinity DataIC50: 200nMAssay Description:The purpose of the wtERBB2, ERBB2-A775_G776insYVMA (ERBB2YVMA), wtEGFR biochemical assay was to evaluate the inhibition (% inhibition and IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 768409BDBM768409((E)-1-(4-(4-((3-methyl-4- ((1-methyl-1H- benzo[d]i...)
Affinity DataIC50: 200nMAssay Description:The purpose of the wtERBB2, ERBB2-A775_G776insYVMA (ERBB2YVMA), wtEGFR biochemical assay was to evaluate the inhibition (% inhibition and IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details

TargetReceptor tyrosine-protein kinase erbB-2 [1-775,'YVMA',776-1255](Human)
Iambic Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 768409BDBM768409((E)-1-(4-(4-((3-methyl-4- ((1-methyl-1H- benzo[d]i...)
Affinity DataIC50: 200nMAssay Description:The purpose of the wtERBB2, ERBB2-A775_G776insYVMA (ERBB2YVMA), wtEGFR biochemical assay was to evaluate the inhibition (% inhibition and IC50 values...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/4/2026
Entry Details