BDBM768418 1-(2-{4-[(3-methyl-4- {[1,2,4]triazolo[1,5- a]pyridin-7- yloxy}phenyl)amino] pyrrolo[2,1-f][1,2,4]triazin- 5-yl}-2,6- diazaspiro[3.4]octan-6- yl)prop-2-en-1-one::US20250276983, Example 155

SMILES C=CC(=O)N1CCC2(C1)CN(c1ccn3ncnc(Nc4ccc(Oc5ccn6ncnc6c5)c(C)c4)c13)C2

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 768418   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM768418(1-(2-{4-[(3-methyl-4- {[1,2,4]triazolo[1,5- a]pyri...)
Affinity DataIC50: 200nMAssay Description:The radioactive signal generated from the aliquot of buffer solution was proportional to the amount of radiolabeled substrate produced, and which is ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/15/2025
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2 [1-775,'YVMA',776-1255](Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM768418(1-(2-{4-[(3-methyl-4- {[1,2,4]triazolo[1,5- a]pyri...)
Affinity DataIC50: 200nMAssay Description:The radioactive signal generated from the aliquot of buffer solution was proportional to the amount of radiolabeled substrate produced, and which is ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/15/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM768418(1-(2-{4-[(3-methyl-4- {[1,2,4]triazolo[1,5- a]pyri...)
Affinity DataIC50: 3.25E+3nMAssay Description:The radioactive signal generated from the aliquot of buffer solution was proportional to the amount of radiolabeled substrate produced, and which is ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/15/2025
Entry Details
US Patent