BDBM769116 (2S,3R)-1-(4-(4-((R)-3-aminotetrahydrofuran-3-yl)phenyl)-7,7-difluoro-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-yl)-2-methylazetidin-3-ol::US12410160, Example 518

SMILES C[C@H]1[C@H](O)CN1c1nc(-c2ccc([C@]3(N)CCOC3)cc2)c2c(n1)C(F)(F)CC2

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 769116   

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769116((2S,3R)-1-(4-(4-((R)-3-aminotetrahydrofuran-3-yl)p...)
Affinity DataIC50: 1.10nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769116((2S,3R)-1-(4-(4-((R)-3-aminotetrahydrofuran-3-yl)p...)
Affinity DataIC50: 2.30nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent