BDBM769175 N-((R)-6-(7,7-difluoro-2-((R)-2-(trifluoromethyl)azetidin-1-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-2,3-dihydrobenzofuran-3-yl)methanesulfonamide::US12410160, Example 577

SMILES CS(=O)(=O)N[C@H]1COc2cc(-c3nc(N4CC[C@@H]4C(F)(F)F)nc4c3CCC4(F)F)ccc21

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 769175   

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769175(N-((R)-6-(7,7-difluoro-2-((R)-2-(trifluoromethyl)a...)
Affinity DataIC50: 0.600nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769175(N-((R)-6-(7,7-difluoro-2-((R)-2-(trifluoromethyl)a...)
Affinity DataIC50: 2.10nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent