BDBM769184 3-[4-[7,7-difluoro-2-[(2R)-2-(trifluoromethyl)azetidin-1-yl]-5,6-dihydrocyclopenta[d]pyrimidin-4-yl]-2-methyl-phenyl]oxetan-3-amine::US12410160, Example 586

SMILES Cc1cc(-c2nc(N3CC[C@@H]3C(F)(F)F)nc3c2CCC3(F)F)ccc1C1(N)COC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 769184   

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769184(3-[4-[7,7-difluoro-2-[(2R)-2-(trifluoromethyl)azet...)
Affinity DataIC50: 0.700nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769184(3-[4-[7,7-difluoro-2-[(2R)-2-(trifluoromethyl)azet...)
Affinity DataIC50: 1.30nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent