BDBM769292 6-[7,7-difluoro-2-[(2S,3R)-3-hydroxy-2-methyl-azetidin-1-yl]-5,6-dihydrocyclopenta[d]pyrimidin-4-yl]-1''-methyl-spiro[2H-benzofuran-3,4''-imidazolidine]-2''-one::US12410160, Example 695

SMILES C[C@H]1[C@H](O)CN1c1nc(-c2ccc3c(c2)OCC32CN(C)C(=O)N2)c2c(n1)C(F)(F)CC2

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 769292   

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769292(6-[7,7-difluoro-2-[(2S,3R)-3-hydroxy-2-methyl-azet...)
Affinity DataIC50: 0.5nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769292(6-[7,7-difluoro-2-[(2S,3R)-3-hydroxy-2-methyl-azet...)
Affinity DataIC50: 16.2nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent