BDBM769493 (R)-3-(5-(7,7-difluoro-2-(2-(trifluoromethyl)azetidin-1-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)thiophen-2-yl)oxetan-3-amine::US12410160, Example 896

SMILES NC1(c2ccc(-c3nc(N4CC[C@@H]4C(F)(F)F)nc4c3CCC4(F)F)s2)COC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 769493   

TargetKetohexokinase(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769493((R)-3-(5-(7,7-difluoro-2-(2-(trifluoromethyl)azeti...)
Affinity DataIC50: 1.70nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Gilead Sciences

US Patent
LigandPNGBDBM769493((R)-3-(5-(7,7-difluoro-2-(2-(trifluoromethyl)azeti...)
Affinity DataIC50: 2.10nMAssay Description:Compounds were tested for KHK enzyme inhibition in a high-throughput 384-well assay format using the ADP-Glo assay (Promega) in buffer consisting of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/17/2025
Entry Details
US Patent