BDBM769861 (6S)-1''-[7-(3-Chloro-2-methyl-4-pyridyl)-6-methyl-pyrazolo[1,5-a]pyrazin-4-yl]-2-methoxy-spiro[4,6-dihydrocyclopenta[d]thiazole-5,4''-piperidine]-6-amine ::US20250282782, Compound 219

SMILES COc1nc2c(s1)[C@@H](N)C1(CCN(c3nc(C)c(-c4ccnc(C)c4Cl)n4nccc34)CC1)C2

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 769861   

LigandPNGBDBM769861((6S)-1'-[7-(3-Chloro-2-methyl-4-pyridyl)-6-methyl-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of SHP2 phosphatase activity was evaluated using human recombinant 6His-Nterm (SEQ ID NO: 1) SHP2 full-length (Thr2-Arg593, R&D system), N...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent