BDBM769874 (5S)-1''-[7-[(2-amino-3-chloro-4-pyridyl)sulfanyl]-6-methyl-pyrazolo[1,5-a]pyrazin-4-yl]spiro[5,7-dihydrocyclopenta[b]pyridine-6,4''-piperidine]-5-amine ::US20250282782, Compound 232

SMILES Cc1nc(N2CCC3(CC2)Cc2ncccc2[C@H]3N)c2ccnn2c1Sc1ccnc(N)c1Cl

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 769874   

LigandPNGBDBM769874((5S)-1'-[7-[(2-amino-3-chloro-4-pyridyl)sulfanyl]-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of SHP2 phosphatase activity was evaluated using human recombinant 6His-Nterm (SEQ ID NO: 1) SHP2 full-length (Thr2-Arg593, R&D system), N...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent