BDBM770187 4-(4-((1R,7S)-2-azabicyclo[5.1.0]octan-2- yl)-8-fluoro-2-(((2R,7aS)-2- fluorotetrahydro-1H-pyrrolizin-7a(5H)- yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5- ethynyl-6-fluoronaphthalen-2-amine::US20250282799, Example 5

SMILES C#Cc1c(F)ccc2cc(N)cc(-c3ncc4c(N5CCCC[C@H]6C[C@H]65)nc(OC[C@@]56CCCN5C[C@H](F)C6)nc4c3F)c12

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 770187   

LigandPNGBDBM770187(4-(4-((1R,7S)-2-azabicyclo[5.1.0]octan-2- yl)-8-fl...)
Affinity DataIC50: 24.2nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

LigandPNGBDBM770187(4-(4-((1R,7S)-2-azabicyclo[5.1.0]octan-2- yl)-8-fl...)
Affinity DataIC50: 234nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent