BDBM770202 5-ethynyl-6-fluoro-4-(8-fluoro-4- ((1R,7R,8S)-8-fluoro-5-oxa-2- azabicyclo[5.1.0]octan-2-yl)-2-(((2R,7aS)- 2-fluorotetrahydro-1H-pyrrolizin-7a(5H)- yl)methoxy-d2)pyrido[4,3-d]pyrimidin-7- yl)naphthalen-2-amine::US20250282799, Example 224

SMILES [2H]C([2H])(Oc1nc(N2CCOC[C@H]3C2[C@H]3F)c2cnc(-c3cc(N)cc4ccc(F)c(C#C)c34)c(F)c2n1)[C@@]12CCCN1C[C@H](F)C2

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 770202   

LigandPNGBDBM770202(5-ethynyl-6-fluoro-4-(8-fluoro-4- ((1R,7R,8S)-8-fl...)
Affinity DataIC50: 3.00E+3nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent

LigandPNGBDBM770202(5-ethynyl-6-fluoro-4-(8-fluoro-4- ((1R,7R,8S)-8-fl...)
Affinity DataIC50: 3.00E+3nMAssay Description:The KRAS: CRAF PPI assay can be utilized to identify KRAS ‘ON’ state inhibitors, as the KRAS protein is loaded with GMPPNP (a non-hydrolyzable GTP an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/22/2025
Entry Details
US Patent