BDBM770436 (R)-N-((3S,4S)-4-(3-chloro-5-fluorophenyl)-1-(5-methylimidazo[1,5-a]pyridine-8-carbonyl)piperidin-3-yl)-2-(2,2,2-trifluoroacetamido)propanamide::WO2024107778, Compound 245

SMILES Cc1ccc(C(=O)N2CC[C@@H](c3cc(F)cc(Cl)c3)[C@H](NC(=O)[C@@H](C)NC(=O)C(F)(F)F)C2)c2cncn12

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 770436   

TargetReplicase polyprotein 1ab(2019-nCoV)
Takeda Pharmaceutical

WIPO
LigandPNGBDBM770436((R)-N-((3S,4S)-4-(3-chloro-5-fluorophenyl)-1-(5-me...)
Affinity DataIC50: 12nMAssay Description: Compounds are 3 fold serially diluted for 10 doses and added to an assay plate (384w format) using ECHO, in duplicate wells. The test concentration ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2024107778

TargetReplicase polyprotein 1ab [L3313F](2019-nCoV)
Takeda Pharmaceutical

WIPO
LigandPNGBDBM770436((R)-N-((3S,4S)-4-(3-chloro-5-fluorophenyl)-1-(5-me...)
Affinity DataIC50: 17nMAssay Description: Compounds are 3 fold serially diluted for 10 doses and added to an assay plate (384w format) using ECHO, in duplicate wells. The test concentration ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2024107778

TargetReplicase polyprotein 1ab(2019-nCoV)
Takeda Pharmaceutical

WIPO
LigandPNGBDBM770436((R)-N-((3S,4S)-4-(3-chloro-5-fluorophenyl)-1-(5-me...)
Affinity DataIC50: 21.8nMAssay Description: Compounds are 3 fold serially diluted for 10 doses and added to an assay plate (384w format) using ECHO, in duplicate wells. The test concentration ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2024107778

TargetReplicase polyprotein 1ab [E3429A](2019-nCoV)
Takeda Pharmaceutical

WIPO
LigandPNGBDBM770436((R)-N-((3S,4S)-4-(3-chloro-5-fluorophenyl)-1-(5-me...)
Affinity DataIC50: 118nMAssay Description: Compounds are 3 fold serially diluted for 10 doses and added to an assay plate (384w format) using ECHO, in duplicate wells. The test concentration ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2024107778

TargetReplicase polyprotein 1ab [L3430F]](2019-nCoV)
Takeda Pharmaceutical

WIPO
LigandPNGBDBM770436((R)-N-((3S,4S)-4-(3-chloro-5-fluorophenyl)-1-(5-me...)
Affinity DataIC50: 398nMAssay Description: Compounds are 3 fold serially diluted for 10 doses and added to an assay plate (384w format) using ECHO, in duplicate wells. The test concentration ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2024107778

TargetReplicase polyprotein 1ab [L3313F,E3429A,L3430F](2019-nCoV)
Takeda Pharmaceutical

WIPO
LigandPNGBDBM770436((R)-N-((3S,4S)-4-(3-chloro-5-fluorophenyl)-1-(5-me...)
Affinity DataIC50: 486nMAssay Description: Compounds are 3 fold serially diluted for 10 doses and added to an assay plate (384w format) using ECHO, in duplicate wells. The test concentration ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2024107778