BDBM770737 (S)-N-(2,2-difluoro-[1,3]dioxolo[4'',5'':4,5]benzo[1,2-d]thiazol-6-yl)-2-((R)-3-(5-((R)-1,2-dihydroxyethyl)-6-oxo-1,6-dihydropyridin-3-yl)-4,4-difluoropiperidin-1-yl)propanamide::WO2025064535, Compound 43

SMILES FC1(OC=2C(=CC3=C(N=C(S3)NC([C@H](C)N3C[C@H](C(CC3)(F)F)C3=CNC(C(=C3)[C@H](CO)O)=O)=O)C2)O1)F

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 770737   

TargetMas-related G-protein coupled receptor member X2(Human)
Deep Apple Therapeutics

WIPO
LigandPNGBDBM770737((S)-N-(2,2-difluoro-[1,3]dioxolo[4',5':4,5]benzo[1...)
Affinity DataIC50: 7.40nMAssay Description:LAD-2 cells were maintained at 37oC with 5% CO2 and grown in complete StemPro-34 media supplemented with 1% L-Glutamate, 1% penicillin/streptomycin, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Deep Apple Therapeutics

WIPO
LigandPNGBDBM770737((S)-N-(2,2-difluoro-[1,3]dioxolo[4',5':4,5]benzo[1...)
Affinity DataIC50: 11nMAssay Description:FlpIn TRex-MRGPRX2-HEK293 cells (herein TRex-MRPGRX2-HEK) stably transfected to express human MRGPRX2 were maintained at 37oC with 5% CO2 and grown i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535