BDBM770770 (S)-2-((S)-4,4-difluoro-3-(6-(hydroxymethyl)-5-oxo-4,5-dihydropyrazin-2-yl)piperidin-1-yl)-N-(2,2-difluoro-[1,3]dioxolo[4'',5'':4,5]benzo[1,2-d]thiazol-6-yl)propanamide::WO2025064535, Compound 91

SMILES FC1([C@@H](CN(CC1)[C@H](C(=O)NC=1SC2=C(N1)C=C1C(=C2)OC(O1)(F)F)C)C=1N=C(C(NC1)=O)CO)F

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 770770   

TargetMas-related G-protein coupled receptor member X2(Human)
Deep Apple Therapeutics

WIPO
LigandPNGBDBM770770((S)-2-((S)-4,4-difluoro-3-(6-(hydroxymethyl)-5-oxo...)
Affinity DataIC50: 36nMAssay Description:FlpIn TRex-MRGPRX2-HEK293 cells (herein TRex-MRPGRX2-HEK) stably transfected to express human MRGPRX2 were maintained at 37oC with 5% CO2 and grown i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Deep Apple Therapeutics

WIPO
LigandPNGBDBM770770((S)-2-((S)-4,4-difluoro-3-(6-(hydroxymethyl)-5-oxo...)
Affinity DataIC50: 68nMAssay Description:LAD-2 cells were maintained at 37oC with 5% CO2 and grown in complete StemPro-34 media supplemented with 1% L-Glutamate, 1% penicillin/streptomycin, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Deep Apple Therapeutics

WIPO
LigandPNGBDBM770770((S)-2-((S)-4,4-difluoro-3-(6-(hydroxymethyl)-5-oxo...)
Affinity DataIC50: 233nMAssay Description:LAD-2 cells were maintained at 37oC with 5% CO2 and grown in complete StemPro-34 media supplemented with 1% L-Glutamate, 1% penicillin/streptomycin, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535