BDBM770857 2-(2-(benzo[d][1,3]dioxol-5-yl)-5-ethyl-6-(4-(3-hydroxy-4-oxo-4,6,7,9-tetrahydropyrimido[2,1-c][1,4]oxazine-2-carbonyl)piperazin-1-yl)-7-oxo-[1,2,4]triazolo[1,5-a]pyrimidin-4(7H)-yl)-N-(2-chloro-4-(trifluoromethyl)phenyl)acetamide::WO2025049746, Example 86

SMILES CCc1c(N2CCN(C(=O)c3nc4n(c(=O)c3O)CCOC4)CC2)c(=O)n2nc(-c3ccc4c(c3)OCO4)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 770857   

LigandPNGBDBM770857(2-(2-(benzo[d][1,3]dioxol-5-yl)-5-ethyl-6-(4-(3-hy...)
Affinity DataIC50: 21.3nMAssay Description:WRN helicase core (8xHis-tev-WRN (480-1251)) was expressed in Sf9 insect cells and purified using HiTrap TALON affinity purification followed by hepa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025049746

LigandPNGBDBM770857(2-(2-(benzo[d][1,3]dioxol-5-yl)-5-ethyl-6-(4-(3-hy...)
Affinity DataIC50: 21.5nMAssay Description:ATPase activity was measured using the ADP-Glo Kinase Assay following the manufacturers recommended protocol. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025049746