BDBM770976 N-[2-chloro-4-(trifluoromethyl)phenyl]-2-{5-ethyl-2-[(2R)-6-fluoro-2-methyl-2,3-dihydro-1-benzofuran-5-yl]-6-[4-(5-hydroxy-6-methylpyrimidine-4-carbonyl)piperazin-1-yl]-7-oxo-[1,2,4]triazolo[1,5-a]pyrimidin-4-yl}acetamide::WO2025049746, Example 250

SMILES CCc1c(N2CCN(C(=O)c3ncnc(C)c3O)CC2)c(=O)n2nc(-c3cc4c(cc3F)O[C@H](C)C4)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 770976   

LigandPNGBDBM770976(N-[2-chloro-4-(trifluoromethyl)phenyl]-2-{5-ethyl-...)
Affinity DataIC50: 20nMAssay Description:WRN helicase core (8xHis-tev-WRN (480-1251)) was expressed in Sf9 insect cells and purified using HiTrap TALON affinity purification followed by hepa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025049746

LigandPNGBDBM770976(N-[2-chloro-4-(trifluoromethyl)phenyl]-2-{5-ethyl-...)
Affinity DataIC50: 22nMAssay Description:ATPase activity was measured using the ADP-Glo Kinase Assay following the manufacturers recommended protocol. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025049746