BDBM771493 (3S)-6-chloro-2''-(5-chloro-2- methylphenyl)-6''-(propan-2-yl)- 5''-(2,4,6-trimethoxypyrimidin-5- yl)-1,2,3'',5''-tetrahydro-2''H- spiro[indole-3,1''-pyrrolo[3,4- c]pyrrole]-2,3''-dione::US12415811, Compound 3

SMILES COc1nc(OC)c(-n2cc3c(c2C(C)C)[C@@]2(C(=O)Nc4cc(Cl)ccc42)N(c2cc(Cl)ccc2C)C3=O)c(OC)n1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 771493   

TargetE3 ubiquitin-protein ligase Mdm2 [1-111](Human)
Adamed Pharma

US Patent
LigandPNGBDBM771493((3S)-6-chloro-2'-(5-chloro-2- methylphenyl)-6'-(p...)
Affinity DataKi:  2.40nMAssay Description:Fluorescence polarization experiments were read on Biotek Cytation 5 reader with the 470 nm excitation and 520 nm emission filters for fluorescein. T...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/29/2025
Entry Details
US Patent