BDBM7717 Oxindole-Based Inhibitor 53::methyl (3Z)-2-oxo-3-{[(4-sulfamoylphenyl)amino]methylidene}-2,3-dihydro-1H-indole-5-carboxylate

SMILES COC(=O)c1ccc2NC(=O)C(C=Nc3ccc(cc3)S(N)(=O)=O)c2c1

InChI Key InChIKey=ATRHQBQEZHPYKB-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 7717   

TargetCyclin-dependent kinase 2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM7717(methyl (3Z)-2-oxo-3-{[(4-sulfamoylphenyl)amino]met...)
Affinity DataIC50: 2.10nMAssay Description:Evaluated for inhibition of human cyclin dependent kinase 2 (CDK2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Glaxosmithkline

LigandPNGBDBM7717(methyl (3Z)-2-oxo-3-{[(4-sulfamoylphenyl)amino]met...)
Affinity DataIC50: 2.10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM7717(methyl (3Z)-2-oxo-3-{[(4-sulfamoylphenyl)amino]met...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM7717(methyl (3Z)-2-oxo-3-{[(4-sulfamoylphenyl)amino]met...)
Affinity DataIC50: 12nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM7717(methyl (3Z)-2-oxo-3-{[(4-sulfamoylphenyl)amino]met...)
Affinity DataIC50: 12nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2006
Entry Details Article
PubMed