BDBM7725 (3Z)-2-oxo-N-(pyridin-3-ylmethyl)-3-[2-(4-sulfamoylphenyl)hydrazin-1-ylidene]-2,3-dihydro-1H-indole-5-carboxamide::3-{[4-(Aminosulfonyl)phenyl]hydrazono}-2-oxo-N-(3-pyridinylmethyl)-2,3-dihydro-1H-indole-5-carboxamide::Oxindole-Based Inhibitor 61

SMILES NS(=O)(=O)c1ccc(NN=C2C(=O)Nc3ccc(cc23)C(=O)NCc2cccnc2)cc1

InChI Key InChIKey=AHTGWLFMAATFNJ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 7725   

TargetCyclin-dependent kinase 2(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM7725(3-{[4-(Aminosulfonyl)phenyl]hydrazono}-2-oxo-N-(3-...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM7725(3-{[4-(Aminosulfonyl)phenyl]hydrazono}-2-oxo-N-(3-...)
Affinity DataIC50: 2.10nMAssay Description:Evaluated for inhibition of human cyclin dependent kinase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Glaxosmithkline

LigandPNGBDBM7725(3-{[4-(Aminosulfonyl)phenyl]hydrazono}-2-oxo-N-(3-...)
Affinity DataIC50: 2.10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2006
Entry Details Article
PubMed
LigandPNGBDBM7725(3-{[4-(Aminosulfonyl)phenyl]hydrazono}-2-oxo-N-(3-...)
Affinity DataIC50: 51nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM7725(3-{[4-(Aminosulfonyl)phenyl]hydrazono}-2-oxo-N-(3-...)
Affinity DataIC50: 51nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed