BDBM774101 2,2-Difluoro-3-((5S,7R)-5-(5-(((S)-1-(3-fluoropropyl)pyrrolidin-3-yl)amino)pyridin-2-yl)-7-methyl-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinolin-6(5H)-yl-2,2-th)propan-1-ol 12::US12428428, Example 12

SMILES [2H]C1([2H])Oc2cc3c(cc2O1)[C@@H](c1ccc(N[C@H]2CCN(CCCF)C2)cn1)N(CC(F)(F)CO)[C@H](C)C3

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 774101   

TargetEstrogen receptor(Human)
Jiangsu Hengrui Medicine Co.

US Patent
LigandPNGBDBM774101(2,2-Difluoro-3-((5S,7R)-5-(5-(((S)-1-(3-fluoroprop...)
Affinity DataIC50: 1.13nMAssay Description:An ERE was cloned upstream of the luciferase gene, and MCF-7/ERE-luciferase monoclonal cells were selected by transfection of MCF-7 (TCHu74, National...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/14/2026
Entry Details
US Patent