BDBM774867 3-(4-((1-(3- Cyano-4-(4- cyano-3-fluorophenyl)- 5-(3-hydroxy-4- methoxyphenyl) pyridin- 2-yl)piperidin-4- yl)amino)methyl)-2- fluorophenyl)-N- hydroxypropanamide formate::US20250304549, Example 201

SMILES COc5ccc(c3cnc(N2CCC(NCc1ccc(CCC(=O)NO)c(F)c1)CC2)c(C#N)c3c4ccc(C#N)c(F)c4)cc5O

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 774867   

TargetLysine-specific histone demethylase 1A(Human)
Sichuan Huiyu Pharmaceutical Co.

US Patent
LigandPNGBDBM774867(3-(4-((1-(3- Cyano-4-(4- cyano-3-fluorophenyl)- 5-...)
Affinity DataIC50: 0.220nMAssay Description:The effect of the compounds on LSD1 enzyme activity was examined using the HTRF technique to assess the level of inhibition. Initially, a master solu...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
Sichuan Huiyu Pharmaceutical Co.

US Patent
LigandPNGBDBM774867(3-(4-((1-(3- Cyano-4-(4- cyano-3-fluorophenyl)- 5-...)
Affinity DataIC50: 4.81nMAssay Description:The effect of the compound on the enzymatic activity of pan-HDAC and two isoforms (HDAC1 and HDAC8) was examined using the HDAC-Glo I/II Assay and Sc...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent

TargetHistone deacetylase 1/8(Human)
Sichuan Huiyu Pharmaceutical Co.

US Patent
LigandPNGBDBM774867(3-(4-((1-(3- Cyano-4-(4- cyano-3-fluorophenyl)- 5-...)
Affinity DataIC50: 7.71nMAssay Description:The effect of the compound on the enzymatic activity of pan-HDAC and two isoforms (HDAC1 and HDAC8) was examined using the HDAC-Glo I/II Assay and Sc...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand Info
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
Sichuan Huiyu Pharmaceutical Co.

US Patent
LigandPNGBDBM774867(3-(4-((1-(3- Cyano-4-(4- cyano-3-fluorophenyl)- 5-...)
Affinity DataIC50: 438nMAssay Description:The effect of the compound on the enzymatic activity of pan-HDAC and two isoforms (HDAC1 and HDAC8) was examined using the HDAC-Glo I/II Assay and Sc...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent