BDBM774897 (E)-3-(4-(2-(4-(6-(4-Aminopiperidin-1-yl)-5-cyano-4-(4-cyano-3-fluorophenyl)pyridin-3-yl)-2-hydroxyphenoxy)ethyl)phenyl)-N-hydroxyacrylamide::US20250304549, Example 231

SMILES N#Cc1ccc(-c2c(-c3ccc(OCCc4ccc(/C=C/C(=O)NO)cc4)c(O)c3)cnc(N3CCC(N)CC3)c2C#N)cc1F

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 774897   

TargetLysine-specific histone demethylase 1A(Human)
Sichuan Huiyu Pharmaceutical Co.

US Patent
LigandPNGBDBM774897((E)-3-(4-(2-(4-(6-(4-Aminopiperidin-1-yl)-5-cyano-...)
Affinity DataIC50: 0.0700nMAssay Description:The effect of the compounds on LSD1 enzyme activity was examined using the HTRF technique to assess the level of inhibition. Initially, a master solu...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent

TargetHistone deacetylase 1/8(Human)
Sichuan Huiyu Pharmaceutical Co.

US Patent
LigandPNGBDBM774897((E)-3-(4-(2-(4-(6-(4-Aminopiperidin-1-yl)-5-cyano-...)
Affinity DataIC50: 82.4nMAssay Description:The effect of the compound on the enzymatic activity of pan-HDAC and two isoforms (HDAC1 and HDAC8) was examined using the HDAC-Glo I/II Assay and Sc...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand Info
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
Sichuan Huiyu Pharmaceutical Co.

US Patent
LigandPNGBDBM774897((E)-3-(4-(2-(4-(6-(4-Aminopiperidin-1-yl)-5-cyano-...)
Affinity DataIC50: 140nMAssay Description:The effect of the compound on the enzymatic activity of pan-HDAC and two isoforms (HDAC1 and HDAC8) was examined using the HDAC-Glo I/II Assay and Sc...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent