BDBM775576 US12435089, Example 44

SMILES COc1ccc(F)cc1[C@@H](C)Nc1ccn2ncc(C3=NOC4(CCCC4)N3)c2n1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 775576   

TargetHigh affinity nerve growth factor receptor [G667C](Human)
Tyk Medicines

US Patent
LigandPNGBDBM775576(US12435089, Example 44)
Affinity DataIC50: 2.75nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/22/2026
Entry Details
US Patent