BDBM775584 US12435089, Example 55

SMILES COC(=O)N1CCC2(CC1)NC(c1cnn3ccc(N[C@H](C)c4cc(F)ccc4OC)nc13)=NO2

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 775584   

TargetProto-oncogene tyrosine-protein kinase ROS (G2032R)(Human)
Tyk Medicines

US Patent
LigandPNGBDBM775584(US12435089, Example 55)
Affinity DataIC50: 0.5nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/22/2026
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Tyk Medicines

US Patent
LigandPNGBDBM775584(US12435089, Example 55)
Affinity DataIC50: 0.5nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/22/2026
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Tyk Medicines

US Patent
LigandPNGBDBM775584(US12435089, Example 55)
Affinity DataIC50: 0.5nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/22/2026
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Tyk Medicines

US Patent
LigandPNGBDBM775584(US12435089, Example 55)
Affinity DataIC50: 0.5nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/22/2026
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Tyk Medicines

US Patent
LigandPNGBDBM775584(US12435089, Example 55)
Affinity DataIC50: 2.75nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/22/2026
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor [G595R](Human)
Tyk Medicines

US Patent
LigandPNGBDBM775584(US12435089, Example 55)
Affinity DataIC50: 2.75nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/22/2026
Entry Details
US Patent