BDBM77573 2-chlorobenzoic acid [[amino-(5-nitro-2-thiazolyl)methylidene]amino] ester::2-chlorobenzoic acid [[amino-(5-nitrothiazol-2-yl)methylene]amino] ester::MLS000859516::O2-(2-chlorobenzoyl)-5-nitro-1,3-thiazole-2-carbohydroximamide::SMR000461293::[[amino-(5-nitro-1,3-thiazol-2-yl)methylidene]amino] 2-chlorobenzoate::[[azanyl-(5-nitro-1,3-thiazol-2-yl)methylidene]amino] 2-chloranylbenzoate::cid_2743682

SMILES CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(C(=O)C3CC3)C4)n[nH]c2c1

InChI Key InChIKey=UKCYXJSMXMIPPN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 77573   

TargetBDNF/NT-3 growth factors receptor(Human)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 77573BDBM77573(cyclopropyl (2-(6-(2-ethyl-5-fluoro-4-hydroxypheny...)
Affinity DataIC50: 4.16nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2026
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 77573BDBM77573(cyclopropyl (2-(6-(2-ethyl-5-fluoro-4-hydroxypheny...)
Affinity DataIC50: 4.21nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2026
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 77573BDBM77573(cyclopropyl (2-(6-(2-ethyl-5-fluoro-4-hydroxypheny...)
Affinity DataIC50: 5.91nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2026
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 77573BDBM77573(cyclopropyl (2-(6-(2-ethyl-5-fluoro-4-hydroxypheny...)
Affinity DataIC50: 12.2nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2026
Entry Details
US Patent