BDBM77577 MLS001163495::N-[(8-hydroxy-7-quinolinyl)(2-naphthyl)methyl]acetamide::N-[(8-hydroxy-7-quinolinyl)-(2-naphthalenyl)methyl]acetamide::N-[(8-hydroxy-7-quinolyl)-(2-naphthyl)methyl]acetamide::N-[(8-hydroxyquinolin-7-yl)-naphthalen-2-ylmethyl]acetamide::N-[naphthalen-2-yl-(8-oxidanylquinolin-7-yl)methyl]ethanamide::SMR000496782::cid_2872439

SMILES CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(C3CCCCN3C(=O)N3CCCCC3N3Cc5nc(-c6n[nH]c7cc(-c8cc(F)c(O)cc8CC)ccc67)[nH]c5C3)C4)n[nH]c2c1

InChI Key InChIKey=XYWUROGWOKDNIK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 77577   

TargetNT-3 growth factor receptor(Human)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 77577BDBM77577((2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazo...)
Affinity DataIC50: 6.32nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2026
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 77577BDBM77577((2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazo...)
Affinity DataIC50: 9.01nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2026
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandChemical structure of BindingDB Monomer ID 77577BDBM77577((2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazo...)
Affinity DataIC50: 30.4nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2026
Entry Details
US Patent