BDBM776287 (5aR,6S,9R)-12-(((S)-2-(difluoromethylene)tetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-2-(8-ethynyl-7-fluoro-3-hydroxynaphthalen-1-yl)-1-fluoro-N-methyl-4-methylene-4,5,5a,6,7,8,9,10-octahydro-3,10a,11,13,14-pentaaza-6,9-methanonaphtho[1,8-ab]heptalene-14-carboxamide::WO2025049274, Example 50

SMILES C=C1C[C@H]2[C@@H]3CC[C@H](CN2c2nc(OC[C@@]45CCCN4C[C@H](F)C5)nc4c(F)c(-c5ccc(F)c6sc(N)c(C#N)c56)c(C(F)(F)F)c1c24)N3

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 776287   

TargetGTPase KRas/RAF proto-oncogene serine/threonine-protein kinase(Human)
880 Winter Street, Suite 1003

WIPO
LigandPNGBDBM776287((5aR,6S,9R)-12-(((S)-2-(difluoromethylene)tetrahyd...)
Affinity DataIC50: 100nMAssay Description:The test compounds were prepared as lOmM stock solution in 100% DMSO. The stock solution was then serially diluted 3 -fold in 100% DMSO to 10 concent...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/24/2026
Entry Details
WIPO WO2025049274

TargetGTPase KRas [G12D]/RAF proto-oncogene serine/threonine-protein kinase(Human)
880 Winter Street, Suite 1003

WIPO
LigandPNGBDBM776287((5aR,6S,9R)-12-(((S)-2-(difluoromethylene)tetrahyd...)
Affinity DataIC50: 100nMAssay Description:The test compounds were prepared as lOmM stock solution in 100% DMSO. The stock solution was then serially diluted 3 -fold in 100% DMSO to 10 concent...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/24/2026
Entry Details
WIPO WO2025049274