BDBM776288 1-(isobutyryloxy)ethyl(4R,11S,14aR)-11-(2-amino-3-cyano-7-fluorothieno[3,2-c]pyridin-4-yl)-12-chloro-10-fluoro-8-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-13-methylene-1,2,3,4,11,12,14,14a-octahydro-1,4-epiminoazepino[1'',2'':1,7]azepino[2,3,4-de]quinazoline-15-carboxylate::WO2025049274, Example 51

SMILES C=C1C[C@H]2[C@@H]3CC[C@H](CN2c2nc(OC[C@@]45CCCN4C[C@H](F)C5)nc4c(F)c(-c5ccc(F)c6sc(N)c(C#N)c56)c(Cl)c1c24)N3C(=O)OC(C)OC(=O)C(C)C

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 776288   

TargetGTPase KRas/RAF proto-oncogene serine/threonine-protein kinase(Human)
880 Winter Street, Suite 1003

WIPO
LigandPNGBDBM776288(1-(isobutyryloxy)ethyl(4R,11S,14aR)-11-(2-amino-3-...)
Affinity DataIC50: 100nMAssay Description:The test compounds were prepared as lOmM stock solution in 100% DMSO. The stock solution was then serially diluted 3 -fold in 100% DMSO to 10 concent...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/24/2026
Entry Details
WIPO WO2025049274

TargetGTPase KRas [G12D]/RAF proto-oncogene serine/threonine-protein kinase(Human)
880 Winter Street, Suite 1003

WIPO
LigandPNGBDBM776288(1-(isobutyryloxy)ethyl(4R,11S,14aR)-11-(2-amino-3-...)
Affinity DataIC50: 100nMAssay Description:The test compounds were prepared as lOmM stock solution in 100% DMSO. The stock solution was then serially diluted 3 -fold in 100% DMSO to 10 concent...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/24/2026
Entry Details
WIPO WO2025049274