BDBM776293 4-((4R,14aR)-12-chloro-8-(((S)-2-(difluoromethylene)tetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-10-fluoro-13-methylene-1,2,3,4,11,12,14,14a-octahydro-1,4-epiminoazepino[1'',2'':1,7]azepino[2,3,4-de]quinazolin-11-yl)-5-ethynyl-6-fluoronaphthalen-2-ol::WO2025049274, Example 56

SMILES C#Cc1cccc2cc(O)cc(-c3c(Cl)c4c5c(nc(OC[C@@]67CCCN6CC(=C(F)F)C7)nc5c3F)N3C[C@H]5CC[C@H](N5)[C@H]3CC4=C)c12

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 776293   

TargetGTPase KRas/RAF proto-oncogene serine/threonine-protein kinase(Human)
880 Winter Street, Suite 1003

WIPO
LigandPNGBDBM776293(4-((4R,14aR)-12-chloro-8-(((S)-2-(difluoromethylen...)
Affinity DataIC50: 100nMAssay Description:The test compounds were prepared as lOmM stock solution in 100% DMSO. The stock solution was then serially diluted 3 -fold in 100% DMSO to 10 concent...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/24/2026
Entry Details
WIPO WO2025049274

TargetGTPase KRas [G12D]/RAF proto-oncogene serine/threonine-protein kinase(Human)
880 Winter Street, Suite 1003

WIPO
LigandPNGBDBM776293(4-((4R,14aR)-12-chloro-8-(((S)-2-(difluoromethylen...)
Affinity DataIC50: 100nMAssay Description:The test compounds were prepared as lOmM stock solution in 100% DMSO. The stock solution was then serially diluted 3 -fold in 100% DMSO to 10 concent...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/24/2026
Entry Details
WIPO WO2025049274