BDBM776298 4-[(4R,7S,8R)-17-({[(7aS)-2-(difluoromethylene)-2,3,5,6,7,7a-hexahydro-1H-pyrrolizin-7a-yl]methyl}oxy)-14-fluoro-10-methylidene-12-(trifluoromethyl)-2,16,18,20-tetrazapentacyclo[13.3.1.14,7.011’19.02’8]icosa-1(19),1(12),13,15(16),17-pentaen-13-yl]-2- amino-7-fluorobenzo [b] thiophene-3-carbonitrile::WO2025049274, Example 61

SMILES C=C1C[C@@H]2[C@H]3CC[C@@H](CN2c2nc(OC[C@@]45CCCN4CC(=C(F)F)C5)nc4c(F)c(-c5ccc(F)c6c5C(C#N)C(N)S6)c(C(F)(F)F)c1c24)N3

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 776298   

TargetGTPase KRas/RAF proto-oncogene serine/threonine-protein kinase(Human)
880 Winter Street, Suite 1003

WIPO
LigandPNGBDBM776298(4-[(4R,7S,8R)-17-({[(7aS)-2-(difluoromethylene)-2,...)
Affinity DataIC50: 100nMAssay Description:The test compounds were prepared as lOmM stock solution in 100% DMSO. The stock solution was then serially diluted 3 -fold in 100% DMSO to 10 concent...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/24/2026
Entry Details
WIPO WO2025049274

TargetGTPase KRas [G12D]/RAF proto-oncogene serine/threonine-protein kinase(Human)
880 Winter Street, Suite 1003

WIPO
LigandPNGBDBM776298(4-[(4R,7S,8R)-17-({[(7aS)-2-(difluoromethylene)-2,...)
Affinity DataIC50: 100nMAssay Description:The test compounds were prepared as lOmM stock solution in 100% DMSO. The stock solution was then serially diluted 3 -fold in 100% DMSO to 10 concent...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/24/2026
Entry Details
WIPO WO2025049274