BDBM776303 6-((4R,11R,14aR)-12-chloro-8-((4-(difluoromethylene)-1,3-dimethylpiperidin-3-yl)methoxy)-10-fluoro-13-methylene-1,2,3,4,11,12,14,14a-octahydro-1,4-epiminoazepino[1'',2'':1,7]azepino[2,3,4-de]quinazolin-11-yl)-4-methyl-5-(trifluoromethyl)pyridin-2-amine::WO2025049274, Example 66

SMILES C=C1C[C@H]2[C@@H]3CC[C@H](CN2c2nc(OCC4(C)CN(C)CCC4=C(F)F)nc4c(F)c(-c5nc(N)cc(C)c5C(F)(F)F)c(Cl)c1c24)N3

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 776303   

TargetGTPase KRas [G12D]/RAF proto-oncogene serine/threonine-protein kinase(Human)
880 Winter Street, Suite 1003

WIPO
LigandPNGBDBM776303(6-((4R,11R,14aR)-12-chloro-8-((4-(difluoromethylen...)
Affinity DataIC50: 100nMAssay Description:The test compounds were prepared as lOmM stock solution in 100% DMSO. The stock solution was then serially diluted 3 -fold in 100% DMSO to 10 concent...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/24/2026
Entry Details
WIPO WO2025049274

TargetGTPase KRas/RAF proto-oncogene serine/threonine-protein kinase(Human)
880 Winter Street, Suite 1003

WIPO
LigandPNGBDBM776303(6-((4R,11R,14aR)-12-chloro-8-((4-(difluoromethylen...)
Affinity DataIC50: 550nMAssay Description:The test compounds were prepared as lOmM stock solution in 100% DMSO. The stock solution was then serially diluted 3 -fold in 100% DMSO to 10 concent...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/24/2026
Entry Details
WIPO WO2025049274