BDBM776308 6-((4R,11R,14aR)-12-chloro-8-(((1S,7a''S)-2,2-difluorodihydro-1''H,3''H-spiro[cyclopropane-1,2''-pyrrolizin]-7a''(5''H)-yl)methoxy)-10-fluoro-13-methylene-1,2,3,4,11,12,14,14a-octahydro-1,4-epiminoazepino[1'',2'':1,7]azepino[2,3,4-de]quinazolin-11-yl)-4-methyl-5-(trifluoromethyl)pyridin-2-amine::WO2025049274, Example 71

SMILES C=C1C[C@H]2[C@@H]3CC[C@H](CN2c2nc(OC[C@@]45CCCN4C[C@]4(CC4(F)F)C5)nc4c(F)c(-c5nc(N)cc(C)c5C(F)(F)F)c(Cl)c1c24)N3

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 776308   

TargetGTPase KRas/RAF proto-oncogene serine/threonine-protein kinase(Human)
880 Winter Street, Suite 1003

WIPO
LigandPNGBDBM776308(6-((4R,11R,14aR)-12-chloro-8-(((1S,7a'S)-2,2-diflu...)
Affinity DataIC50: 100nMAssay Description:The test compounds were prepared as lOmM stock solution in 100% DMSO. The stock solution was then serially diluted 3 -fold in 100% DMSO to 10 concent...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/24/2026
Entry Details
WIPO WO2025049274

TargetGTPase KRas [G12D]/RAF proto-oncogene serine/threonine-protein kinase(Human)
880 Winter Street, Suite 1003

WIPO
LigandPNGBDBM776308(6-((4R,11R,14aR)-12-chloro-8-(((1S,7a'S)-2,2-diflu...)
Affinity DataIC50: 100nMAssay Description:The test compounds were prepared as lOmM stock solution in 100% DMSO. The stock solution was then serially diluted 3 -fold in 100% DMSO to 10 concent...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/24/2026
Entry Details
WIPO WO2025049274