BDBM780143 3-(imidazo[1,2-b]pyridazin-3- ylethynyl)-N-(4-(((2-(4-(6- methoxypyrimidin-4-yl)piperazin- 1-yl)ethyl)amino)methyl)-3- (trifluoromethyl)phenyl)-4- methylbenzamide::US12440494, Compound 4

SMILES COc1cc(N2CCN(CCNCc3ccc(NC(=O)c4ccc(C)c(C#Cc5cnc6cccnn56)c4)cc3C(F)(F)F)CC2)ncn1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 780143   

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Albert Einstein College of Medicine

US Patent
LigandPNGBDBM780143(3-(imidazo[1,2-b]pyridazin-3- ylethynyl)-N-(4-(((2...)
Affinity DataIC50: 48nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent