BDBM781897 (S)-2-amino-N-(1-(8-((1-cyclopropyl-1H-pyrazol-4-yl)ethynyl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide::US12447151, Example 1

SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cnn(C4CC4)c3)c2c(=O)n1-c1ccccc1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 781897   

TargetPhosphatidylinositol 3-kinase C2 domain-containing subunit gamma(Human)
HIS Pharmaceutical Co.

US Patent
LigandPNGBDBM781897((S)-2-amino-N-(1-(8-((1-cyclopropyl-1H-pyrazol-4-y...)
Affinity DataIC50: 0.460nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/9/2026
Entry Details US Patent

LigandPNGBDBM781897((S)-2-amino-N-(1-(8-((1-cyclopropyl-1H-pyrazol-4-y...)
Affinity DataIC50: 101nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/9/2026
Entry Details US Patent

LigandPNGBDBM781897((S)-2-amino-N-(1-(8-((1-cyclopropyl-1H-pyrazol-4-y...)
Affinity DataIC50: 237nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/9/2026
Entry Details US Patent

LigandPNGBDBM781897((S)-2-amino-N-(1-(8-((1-cyclopropyl-1H-pyrazol-4-y...)
Affinity DataIC50: 461nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/9/2026
Entry Details US Patent