BDBM783188 US20250326769, Example 55

SMILES C[C@H]5Oc1cc(cnc1N)c2c(C#N)n(COCC[Si](C)(C)C)nc2C(=O)c3cccnc3c4c(F)cc(F)cc45

InChI Key

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 783188   

TargetALK tyrosine kinase receptor [I1171N,D1203N](Homo sapiens (Human))
Nuvalent

US Patent
LigandPNGBDBM783188(US20250326769, Example 55)
Affinity DataKi: <50nMAssay Description:First, 250 nL of compound dissolved in DMSO (100-fold of the desired concentration) was dispensed into a 384-well plate. A 12.5 μL substrate solution...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/11/2026
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Nuvalent

US Patent
LigandPNGBDBM783188(US20250326769, Example 55)
Affinity DataKi: >500nMAssay Description:First, 250 nL of compound dissolved in DMSO (100-fold of the desired concentration) was dispensed into a 384-well plate. A 12.5 μL substrate solution...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/11/2026
Entry Details
US Patent