BDBM783338 2,2'-((3R,3'R,6R,6'R)- (((2S,2'S)-((1,3- phenylenebis(oxy))bis (methylene))bis (morpholine-2,4- diyl))bis(methylene)) bis(3-methylpiperazine- 6,1-diyl))bis(1-(3,3- dimethyl-6-(pyridin-3- ylmethyl)-2,3-dihydro- 1H-pyrrolo[3,2- b]pyridin-1-yl)ethan-1- one)::US20250326771, Compound 146

SMILES C[C@@H]1CN(CC(=O)N2CC(C)(C)c3ncc(Cc4cccnc4)cc32)[C@@H](CN2CCO[C@H](COc3cccc(OC[C@@H]4CN(C[C@H]5CN[C@H](C)CN5CC(=O)N5CC(C)(C)c6ncc(Cc7cccnc7)cc65)CCO4)c3)C2)CN1

InChI Key

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 783338   

TargetBaculoviral IAP repeat-containing protein 2 [269-336](Human)
Viiv Healthcare

US Patent
LigandPNGBDBM783338(2,2'-((3R,3'R,6R,6'R)- (((2S,2'S)-((1,3- phenylene...)
Affinity DataIC50: 5.35nMAssay Description:The BIR domain binding assays are FRET based competition assays that utilize His-tagged versions of each of the BIR2 and BIR3 domains from cIAP1, cIA...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/11/2026
Entry Details
US Patent

TargetBaculoviral IAP repeat-containing protein 3 [255-322](Human)
Viiv Healthcare

US Patent
LigandPNGBDBM783338(2,2'-((3R,3'R,6R,6'R)- (((2S,2'S)-((1,3- phenylene...)
Affinity DataIC50: 5.35nMAssay Description:The BIR domain binding assays are FRET based competition assays that utilize His-tagged versions of each of the BIR2 and BIR3 domains from cIAP1, cIA...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/11/2026
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase XIAP [265-330](Human)
Viiv Healthcare

US Patent
LigandPNGBDBM783338(2,2'-((3R,3'R,6R,6'R)- (((2S,2'S)-((1,3- phenylene...)
Affinity DataIC50: 282nMAssay Description:The BIR domain binding assays are FRET based competition assays that utilize His-tagged versions of each of the BIR2 and BIR3 domains from cIAP1, cIA...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/11/2026
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase XIAP [163-230](Human)
Viiv Healthcare

US Patent
LigandPNGBDBM783338(2,2'-((3R,3'R,6R,6'R)- (((2S,2'S)-((1,3- phenylene...)
Affinity DataIC50: 3.57E+4nMAssay Description:The BIR domain binding assays are FRET based competition assays that utilize His-tagged versions of each of the BIR2 and BIR3 domains from cIAP1, cIA...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/11/2026
Entry Details
US Patent

TargetBaculoviral IAP repeat-containing protein 3 [169-235](Human)
Viiv Healthcare

US Patent
LigandPNGBDBM783338(2,2'-((3R,3'R,6R,6'R)- (((2S,2'S)-((1,3- phenylene...)
Affinity DataIC50: 3.57E+4nMAssay Description:The BIR domain binding assays are FRET based competition assays that utilize His-tagged versions of each of the BIR2 and BIR3 domains from cIAP1, cIA...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/11/2026
Entry Details
US Patent

TargetBaculoviral IAP repeat-containing protein 2 [184-250](Human)
Viiv Healthcare

US Patent
LigandPNGBDBM783338(2,2'-((3R,3'R,6R,6'R)- (((2S,2'S)-((1,3- phenylene...)
Affinity DataIC50: 3.57E+4nMAssay Description:The BIR domain binding assays are FRET based competition assays that utilize His-tagged versions of each of the BIR2 and BIR3 domains from cIAP1, cIA...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/11/2026
Entry Details
US Patent