BDBM783663 2-(2-(2-(3'',6''-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9''-xanthene]-5-carboxamido)ethoxy)ethoxy)ethyl 2-((2R,5S)-4-(6-cyano-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridin-4-yl)-2,5-dimethylpiperazin-1-yl)-2-(4-fluorophenyl)acetate::US12454531, Example 68

SMILES N#Cc1ccc2c(n1)c(N1C[C@@H](C)N(C(C(=O)OCCOCCOCCNC(=O)c3ccc4c(c3)C(=O)OC43c4ccc(O)cc4Oc4cc(O)ccc43)c3ccc(F)cc3)C[C@@H]1C)cc(=O)n2C

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 783663   

TargetDiacylglycerol kinase alpha(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM783663(2-(2-(2-(3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofu...)
Affinity DataIC50: 160nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/17/2026
Entry Details US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM783663(2-(2-(2-(3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofu...)
Affinity DataIC50: 410nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/17/2026
Entry Details US Patent