BDBM783669 US20250333393, Compound 4S

SMILES [2H]C([2H])([2H])Oc2c(c1cnn(C)n1)ccnc2Nc5cc(NC(=O)[C@H]3CC34CC4)ncc5C(=O)CC

InChI Key

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 783669   

TargetNon-receptor tyrosine-protein kinase TYK2 [556-871](Human)
Zhejiang Wenda Pharmaceutical Technology Co.

US Patent
LigandPNGBDBM783669(US20250333393, Compound 4S)
Affinity DataIC50: 0.290nMAssay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/19/2026
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1 [583-855](Human)
Zhejiang Wenda Pharmaceutical Technology Co.

US Patent
LigandPNGBDBM783669(US20250333393, Compound 4S)
Affinity DataIC50: 22nMAssay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/19/2026
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Zhejiang Wenda Pharmaceutical Technology Co.

US Patent
LigandPNGBDBM783669(US20250333393, Compound 4S)
Affinity DataIC50: 5.42E+3nMAssay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/19/2026
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3 [811-1124](Human)
Zhejiang Wenda Pharmaceutical Technology Co.

US Patent
LigandPNGBDBM783669(US20250333393, Compound 4S)
Affinity DataIC50: 9.90E+3nMAssay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/19/2026
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Zhejiang Wenda Pharmaceutical Technology Co.

US Patent
LigandPNGBDBM783669(US20250333393, Compound 4S)
Affinity DataIC50: 9.90E+3nMAssay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/19/2026
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2 [886-1187](Human)
Zhejiang Wenda Pharmaceutical Technology Co.

US Patent
LigandPNGBDBM783669(US20250333393, Compound 4S)
Affinity DataIC50: 9.90E+3nMAssay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/19/2026
Entry Details
US Patent