BDBM783847 methyl 4-((1-(3-(8-fluoro-5- methyl-1-oxo-1,2- dihydroisoquinolin-3- yl)propanoyl)piperidin-4- yl)amino)benzoate::US12459899, Example 268

SMILES COC(=O)c1ccc(NC2CCN(C(=O)CCc3cc4c(C)ccc(F)c4c(=O)[nH]3)CC2)cc1

InChI Key InChIKey=JQLWWKFFMNPWFG-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 783847   

TargetPoly [ADP-ribose] polymerase 1(Human)
Digmbio

US Patent
LigandChemical structure of BindingDB Monomer ID 783847BDBM783847(methyl 4-((1-(3-(8-fluoro-5- methyl-1-oxo-1,2- dih...)
Affinity DataIC50: 1nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/23/2026
Entry Details
US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Digmbio

US Patent
LigandChemical structure of BindingDB Monomer ID 783847BDBM783847(methyl 4-((1-(3-(8-fluoro-5- methyl-1-oxo-1,2- dih...)
Affinity DataIC50: 8.59nMAssay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/23/2026
Entry Details
US Patent