BDBM783848 8-fluoro-3-(3-(3-hydroxy-8- azabicyclo[3.2.1]octan-8- yl)propyl)isoquinolin-1(2H)- one::US12459899, Example 272

SMILES O=c1[nH]c(CCCN2C3CCC2CC(O)C3)cc2cccc(F)c12

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 783848   

TargetPoly [ADP-ribose] polymerase 1(Human)
Digmbio

US Patent
LigandPNGBDBM783848(8-fluoro-3-(3-(3-hydroxy-8- azabicyclo[3.2.1]octan...)
Affinity DataIC50: 0.650nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/23/2026
Entry Details US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Digmbio

US Patent
LigandPNGBDBM783848(8-fluoro-3-(3-(3-hydroxy-8- azabicyclo[3.2.1]octan...)
Affinity DataIC50: 3.27nMAssay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/23/2026
Entry Details US Patent