BDBM783954 8-fluoro-3-(3-(6-fluoro-3'',6''- dihydro-[3,4''-bipyridine]- 1''(2''H)-yl)propyl)isoquinolin- 1(2H)-one::US12459899, Example 43

SMILES O=c1[nH]c(CCCN2CC=C(c3ccc(F)nc3)CC2)cc2cccc(F)c12

InChI Key InChIKey=LFHKXRNOQNIPAC-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 783954   

TargetPoly [ADP-ribose] polymerase 1(Human)
Digmbio

US Patent
LigandChemical structure of BindingDB Monomer ID 783954BDBM783954(8-fluoro-3-(3-(6-fluoro-3',6'- dihydro-[3,4'-bipyr...)
Affinity DataIC50: 1nMAssay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/23/2026
Entry Details
US Patent