BDBM783958 4-(1-(3-(7-fluoro-1-oxo-1,2- dihydroisoquinolin-3- yl)propyl)-1,2,3,6- tetrahydropyridin-4- yl)benzonitrile::US12459899, Example 47

SMILES N#Cc1ccc(C2=CCN(CCCc3cc4ccc(F)cc4c(=O)[nH]3)CC2)cc1

InChI Key

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 783958   

TargetPoly [ADP-ribose] polymerase 1(Human)
Digmbio

US Patent
LigandPNGBDBM783958(4-(1-(3-(7-fluoro-1-oxo-1,2- dihydroisoquinolin-3-...)
Affinity DataIC50: 0.200nMAssay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/23/2026
Entry Details
US Patent