BDBM784217 (R)-4-(2-((4-(2-(methyl-d3)phenyl)-1-oxo-1,2-dihydroisoquinolin-7-yl)oxy)propanoyl)piperazine-1-carboxamide::US20250340516, Example 74

SMILES [2H]C([2H])([2H])c1ccccc1-c1c[nH]c(=O)c2cc(O[C@H](C)C(=O)N3CCN(C(N)=O)CC3)ccc12

InChI Key

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 784217   

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM784217((R)-4-(2-((4-(2-(methyl-d3)phenyl)-1-oxo-1,2-dihyd...)
Affinity DataIC50: 80nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details
US Patent