BDBM785344 US12466840, Example Ex-1

SMILES F/C=C\9CN1CCC[C@@]1(COc6nc7c5c(nc(c3c(C2CC2)c(Cl)cc4[nH]ncc34)c(F)c5n6)OC[C@@H]8COCCCN78)C9

InChI Key

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 785344   

TargetGTPase KRas [G12D](Human)TBA
LigandChemical structure of BindingDB Monomer ID 785344BDBM785344(US12466840, Example Ex-1)
Affinity DataIC50: 0.670nMAssay Description:To assemble the preformed TR-FRET complexes, each biotinylated RAS protein is diluted to 2 μM in an EDTA Buffer (20 mM HEPES pH 7.5, 50 mM sodium chl...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details

TargetGTPase KRas [G12R](Human)TBA
LigandChemical structure of BindingDB Monomer ID 785344BDBM785344(US12466840, Example Ex-1)
Affinity DataIC50: 0.690nMAssay Description:To assemble the preformed TR-FRET complexes, each biotinylated RAS protein is diluted to 2 μM in an EDTA Buffer (20 mM HEPES pH 7.5, 50 mM sodium chl...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details

TargetGTPase KRas [G12S](Human)TBA
LigandChemical structure of BindingDB Monomer ID 785344BDBM785344(US12466840, Example Ex-1)
Affinity DataIC50: 0.690nMAssay Description:To assemble the preformed TR-FRET complexes, each biotinylated RAS protein is diluted to 2 μM in an EDTA Buffer (20 mM HEPES pH 7.5, 50 mM sodium chl...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details

TargetGTPase KRas [G12A](Human)TBA
LigandChemical structure of BindingDB Monomer ID 785344BDBM785344(US12466840, Example Ex-1)
Affinity DataIC50: 0.690nMAssay Description:To assemble the preformed TR-FRET complexes, each biotinylated RAS protein is diluted to 2 μM in an EDTA Buffer (20 mM HEPES pH 7.5, 50 mM sodium chl...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details

TargetGTPase KRas(Human)TBA
LigandChemical structure of BindingDB Monomer ID 785344BDBM785344(US12466840, Example Ex-1)
Affinity DataIC50: 0.870nMAssay Description:To assemble the preformed TR-FRET complexes, each biotinylated RAS protein is diluted to 2 μM in an EDTA Buffer (20 mM HEPES pH 7.5, 50 mM sodium chl...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details

TargetGTPase KRas [G12V](Human)TBA
LigandChemical structure of BindingDB Monomer ID 785344BDBM785344(US12466840, Example Ex-1)
Affinity DataIC50: 1.30nMAssay Description:To assemble the preformed TR-FRET complexes, each biotinylated RAS protein is diluted to 2 μM in an EDTA Buffer (20 mM HEPES pH 7.5, 50 mM sodium chl...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details

TargetGTPase KRas [Q61H](Human)TBA
LigandChemical structure of BindingDB Monomer ID 785344BDBM785344(US12466840, Example Ex-1)
Affinity DataIC50: 1.40nMAssay Description:To assemble the preformed TR-FRET complexes, each biotinylated RAS protein is diluted to 2 μM in an EDTA Buffer (20 mM HEPES pH 7.5, 50 mM sodium chl...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details

TargetGTPase KRas [G13D](Human)TBA
LigandChemical structure of BindingDB Monomer ID 785344BDBM785344(US12466840, Example Ex-1)
Affinity DataIC50: 3.70nMAssay Description:To assemble the preformed TR-FRET complexes, each biotinylated RAS protein is diluted to 2 μM in an EDTA Buffer (20 mM HEPES pH 7.5, 50 mM sodium chl...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details

TargetGTPase KRas [G12C](Human)TBA
LigandChemical structure of BindingDB Monomer ID 785344BDBM785344(US12466840, Example Ex-1)
Affinity DataIC50: 6.90nMAssay Description:To assemble the preformed TR-FRET complexes, each biotinylated RAS protein is diluted to 2 μM in an EDTA Buffer (20 mM HEPES pH 7.5, 50 mM sodium chl...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details

TargetGTPase HRas(Human)TBA
LigandChemical structure of BindingDB Monomer ID 785344BDBM785344(US12466840, Example Ex-1)
Affinity DataIC50: 1.11E+4nMAssay Description:To assemble the preformed TR-FRET complexes, each biotinylated RAS protein is diluted to 2 μM in an EDTA Buffer (20 mM HEPES pH 7.5, 50 mM sodium chl...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details

TargetGTPase NRas(Human)TBA
LigandChemical structure of BindingDB Monomer ID 785344BDBM785344(US12466840, Example Ex-1)
Affinity DataIC50: 1.11E+4nMAssay Description:To assemble the preformed TR-FRET complexes, each biotinylated RAS protein is diluted to 2 μM in an EDTA Buffer (20 mM HEPES pH 7.5, 50 mM sodium chl...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details