BDBM785345 US12466840, Example Ex-2

SMILES CCc1c(F)cc2[nH]ncc2c1-c1nc2c3c(nc(OC[C@@]45CCCN4C[C@H](F)C5)nc3c1F)N1CCCOC[C@H]1CO2

InChI Key InChIKey=UQZTUUZNOCEUHU-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 785345   

TargetGTPase KRas [G12D](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 785345BDBM785345(US12466840, Example Ex-2)
Affinity DataIC50: 0.650nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/2/2026
Entry Details
US Patent

TargetGTPase KRas [G12R](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 785345BDBM785345(US12466840, Example Ex-2)
Affinity DataIC50: 0.690nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/2/2026
Entry Details
US Patent

TargetGTPase KRas [G12S](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 785345BDBM785345(US12466840, Example Ex-2)
Affinity DataIC50: 0.690nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/2/2026
Entry Details
US Patent

TargetGTPase KRas [G12A](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 785345BDBM785345(US12466840, Example Ex-2)
Affinity DataIC50: 0.690nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/2/2026
Entry Details
US Patent

TargetGTPase KRas [G13D](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 785345BDBM785345(US12466840, Example Ex-2)
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/2/2026
Entry Details
US Patent

TargetGTPase KRas(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 785345BDBM785345(US12466840, Example Ex-2)
Affinity DataIC50: 1.10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/2/2026
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 785345BDBM785345(US12466840, Example Ex-2)
Affinity DataIC50: 1.20nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/2/2026
Entry Details
US Patent

TargetGTPase KRas [G12V](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 785345BDBM785345(US12466840, Example Ex-2)
Affinity DataIC50: 1.30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/2/2026
Entry Details
US Patent

TargetGTPase KRas [G12C](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 785345BDBM785345(US12466840, Example Ex-2)
Affinity DataIC50: 3.20nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/2/2026
Entry Details
US Patent

TargetGTPase HRas(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 785345BDBM785345(US12466840, Example Ex-2)
Affinity DataIC50: 2.74E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/2/2026
Entry Details
US Patent

TargetGTPase NRas(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 785345BDBM785345(US12466840, Example Ex-2)
Affinity DataIC50: 7.02E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/2/2026
Entry Details
US Patent