BDBM785347 US12466840, Example Ex-4

SMILES CCc1c(F)ccc2cc3[nH]ncc3c(-c3nc4c5c(nc(OC[C@@]67CCCN6C/C(=C\F)C7)nc5c3F)N3CCCOC[C@H]3CO4)c12

InChI Key

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 785347   

TargetGTPase KRas [G12R](Human)TBA
LigandChemical structure of BindingDB Monomer ID 785347BDBM785347(US12466840, Example Ex-4)
Affinity DataIC50: 0.690nMAssay Description:To assemble the preformed TR-FRET complexes, each biotinylated RAS protein is diluted to 2 μM in an EDTA Buffer (20 mM HEPES pH 7.5, 50 mM sodium chl...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details

TargetGTPase KRas [G12S](Human)TBA
LigandChemical structure of BindingDB Monomer ID 785347BDBM785347(US12466840, Example Ex-4)
Affinity DataIC50: 0.690nMAssay Description:To assemble the preformed TR-FRET complexes, each biotinylated RAS protein is diluted to 2 μM in an EDTA Buffer (20 mM HEPES pH 7.5, 50 mM sodium chl...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details

TargetGTPase KRas [G12A](Human)TBA
LigandChemical structure of BindingDB Monomer ID 785347BDBM785347(US12466840, Example Ex-4)
Affinity DataIC50: 0.690nMAssay Description:To assemble the preformed TR-FRET complexes, each biotinylated RAS protein is diluted to 2 μM in an EDTA Buffer (20 mM HEPES pH 7.5, 50 mM sodium chl...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details

TargetGTPase KRas(Human)TBA
LigandChemical structure of BindingDB Monomer ID 785347BDBM785347(US12466840, Example Ex-4)
Affinity DataIC50: 0.690nMAssay Description:To assemble the preformed TR-FRET complexes, each biotinylated RAS protein is diluted to 2 μM in an EDTA Buffer (20 mM HEPES pH 7.5, 50 mM sodium chl...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details

TargetGTPase KRas [G12D](Human)TBA
LigandChemical structure of BindingDB Monomer ID 785347BDBM785347(US12466840, Example Ex-4)
Affinity DataIC50: 0.690nMAssay Description:To assemble the preformed TR-FRET complexes, each biotinylated RAS protein is diluted to 2 μM in an EDTA Buffer (20 mM HEPES pH 7.5, 50 mM sodium chl...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details

TargetGTPase KRas [G12V](Human)TBA
LigandChemical structure of BindingDB Monomer ID 785347BDBM785347(US12466840, Example Ex-4)
Affinity DataIC50: 0.830nMAssay Description:To assemble the preformed TR-FRET complexes, each biotinylated RAS protein is diluted to 2 μM in an EDTA Buffer (20 mM HEPES pH 7.5, 50 mM sodium chl...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details

TargetGTPase KRas [G13D](Human)TBA
LigandChemical structure of BindingDB Monomer ID 785347BDBM785347(US12466840, Example Ex-4)
Affinity DataIC50: 0.890nMAssay Description:To assemble the preformed TR-FRET complexes, each biotinylated RAS protein is diluted to 2 μM in an EDTA Buffer (20 mM HEPES pH 7.5, 50 mM sodium chl...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details

TargetGTPase KRas [Q61H](Human)TBA
LigandChemical structure of BindingDB Monomer ID 785347BDBM785347(US12466840, Example Ex-4)
Affinity DataIC50: 1nMAssay Description:To assemble the preformed TR-FRET complexes, each biotinylated RAS protein is diluted to 2 μM in an EDTA Buffer (20 mM HEPES pH 7.5, 50 mM sodium chl...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details

TargetGTPase KRas [G12C](Human)TBA
LigandChemical structure of BindingDB Monomer ID 785347BDBM785347(US12466840, Example Ex-4)
Affinity DataIC50: 2.90nMAssay Description:To assemble the preformed TR-FRET complexes, each biotinylated RAS protein is diluted to 2 μM in an EDTA Buffer (20 mM HEPES pH 7.5, 50 mM sodium chl...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details

TargetGTPase HRas(Human)TBA
LigandChemical structure of BindingDB Monomer ID 785347BDBM785347(US12466840, Example Ex-4)
Affinity DataIC50: 1.28E+3nMAssay Description:To assemble the preformed TR-FRET complexes, each biotinylated RAS protein is diluted to 2 μM in an EDTA Buffer (20 mM HEPES pH 7.5, 50 mM sodium chl...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details

TargetGTPase NRas(Human)TBA
LigandChemical structure of BindingDB Monomer ID 785347BDBM785347(US12466840, Example Ex-4)
Affinity DataIC50: 2.82E+3nMAssay Description:To assemble the preformed TR-FRET complexes, each biotinylated RAS protein is diluted to 2 μM in an EDTA Buffer (20 mM HEPES pH 7.5, 50 mM sodium chl...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details