BDBM785349 US12466840, Example Ex-6

SMILES CCc1c(F)ccc2cc3[nH]nc(C)c3c(-c3nc4c5c(nc(OC[C@@]67CCCN6C[C@H](F)C7)nc5c3F)N3CCCOC[C@H]3CO4)c12

InChI Key

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 785349   

TargetGTPase KRas [G12A](Human)TBA
LigandChemical structure of BindingDB Monomer ID 785349BDBM785349(US12466840, Example Ex-6)
Affinity DataIC50: 1nMAssay Description:To assemble the preformed TR-FRET complexes, each biotinylated RAS protein is diluted to 2 μM in an EDTA Buffer (20 mM HEPES pH 7.5, 50 mM sodium chl...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details

TargetGTPase KRas [G12R](Human)TBA
LigandChemical structure of BindingDB Monomer ID 785349BDBM785349(US12466840, Example Ex-6)
Affinity DataIC50: 1.20nMAssay Description:To assemble the preformed TR-FRET complexes, each biotinylated RAS protein is diluted to 2 μM in an EDTA Buffer (20 mM HEPES pH 7.5, 50 mM sodium chl...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details

TargetGTPase KRas [G12S](Human)TBA
LigandChemical structure of BindingDB Monomer ID 785349BDBM785349(US12466840, Example Ex-6)
Affinity DataIC50: 1.20nMAssay Description:To assemble the preformed TR-FRET complexes, each biotinylated RAS protein is diluted to 2 μM in an EDTA Buffer (20 mM HEPES pH 7.5, 50 mM sodium chl...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details

TargetGTPase KRas [G12D](Human)TBA
LigandChemical structure of BindingDB Monomer ID 785349BDBM785349(US12466840, Example Ex-6)
Affinity DataIC50: 1.30nMAssay Description:To assemble the preformed TR-FRET complexes, each biotinylated RAS protein is diluted to 2 μM in an EDTA Buffer (20 mM HEPES pH 7.5, 50 mM sodium chl...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details

TargetGTPase KRas [G12V](Human)TBA
LigandChemical structure of BindingDB Monomer ID 785349BDBM785349(US12466840, Example Ex-6)
Affinity DataIC50: 1.5nMAssay Description:To assemble the preformed TR-FRET complexes, each biotinylated RAS protein is diluted to 2 μM in an EDTA Buffer (20 mM HEPES pH 7.5, 50 mM sodium chl...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details

TargetGTPase KRas(Human)TBA
LigandChemical structure of BindingDB Monomer ID 785349BDBM785349(US12466840, Example Ex-6)
Affinity DataIC50: 1.60nMAssay Description:To assemble the preformed TR-FRET complexes, each biotinylated RAS protein is diluted to 2 μM in an EDTA Buffer (20 mM HEPES pH 7.5, 50 mM sodium chl...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details

TargetGTPase KRas [Q61H](Human)TBA
LigandChemical structure of BindingDB Monomer ID 785349BDBM785349(US12466840, Example Ex-6)
Affinity DataIC50: 1.80nMAssay Description:To assemble the preformed TR-FRET complexes, each biotinylated RAS protein is diluted to 2 μM in an EDTA Buffer (20 mM HEPES pH 7.5, 50 mM sodium chl...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details

TargetGTPase KRas [G13D](Human)TBA
LigandChemical structure of BindingDB Monomer ID 785349BDBM785349(US12466840, Example Ex-6)
Affinity DataIC50: 1.90nMAssay Description:To assemble the preformed TR-FRET complexes, each biotinylated RAS protein is diluted to 2 μM in an EDTA Buffer (20 mM HEPES pH 7.5, 50 mM sodium chl...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details

TargetGTPase KRas [G12C](Human)TBA
LigandChemical structure of BindingDB Monomer ID 785349BDBM785349(US12466840, Example Ex-6)
Affinity DataIC50: 6.5nMAssay Description:To assemble the preformed TR-FRET complexes, each biotinylated RAS protein is diluted to 2 μM in an EDTA Buffer (20 mM HEPES pH 7.5, 50 mM sodium chl...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details

TargetGTPase HRas(Human)TBA
LigandChemical structure of BindingDB Monomer ID 785349BDBM785349(US12466840, Example Ex-6)
Affinity DataIC50: 5.52E+3nMAssay Description:To assemble the preformed TR-FRET complexes, each biotinylated RAS protein is diluted to 2 μM in an EDTA Buffer (20 mM HEPES pH 7.5, 50 mM sodium chl...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details

TargetGTPase NRas(Human)TBA
LigandChemical structure of BindingDB Monomer ID 785349BDBM785349(US12466840, Example Ex-6)
Affinity DataIC50: 1.01E+4nMAssay Description:To assemble the preformed TR-FRET complexes, each biotinylated RAS protein is diluted to 2 μM in an EDTA Buffer (20 mM HEPES pH 7.5, 50 mM sodium chl...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
3/2/2026
Entry Details